Hyzaar 50 12.5 | 28Tab

Product Name

• Hyzaar, Reduce Blood Pressure, Prevent Hypertension Complication - 28 Tablets

Scientific Name

• Losartan 50 Mg + Hydrochlorothiazide 12.5 Mg Tablets

Category Of Hyzaar Tablets

• Anti-Hypertensive Drugs

Mechanism Of Action Of Losartan & Hydrochlorothiazide

• Losartan is an angiotensin II receptor blocker (ARB). It works by blocking a substance in the body that causes blood vessels to constrict.
• As a result, losartan relaxes the blood vessels. This lowers blood pressure and increases the supply of blood and oxygen to the heart.
• Hydrochlorothiazide inhibits sodium chloride transport in the distal convoluted tubule. More sodium is then excreted in the kidney with accompanying fluid.
• Thus it increases urine excretion, which by turn decreases blood volume and finally blood pressure.
• On long-term usage, thiazide diuretic (TZD)-mediated chronic reduction of arterial pressure is thought to occur through decreased total peripheral vascular resistance.

Therapeutic Indications Of Hyzaar Tablets

• Treatment of essential hypertension.
• High blood pressure is a common condition in which the long-term force of the blood against your artery walls is high enough that it may eventually cause health problems, such as heart disease.

Method Of Administration Of Hyzaar Tablets

• The tablets can be taken with or without food.
• Swallow the tablets with a sufficient amount of water (e.g. One glass).
• If possible, take your daily dose at the same time each day, for example at breakfast time.
• Always take this medicine exactly as your doctor has told you. Check with your doctor or pharmacist if you are not sure.
• The usual dose of losartan potassium and hydrochlorothiazide for most patients with high blood pressure is 1 tablet of losartan potassium and hydrochlorothiazide 50 mg/12.5 mg per day to control blood pressure over 24 hours.
• This can be increased to 2 tablets once daily of losartan / hydrochlorothiazide 50 mg/12.5 mg film-coated tablets.
• The maximum daily dose is 2 tablets per day of losartan / hydrochlorothiazide 50 mg/12.5 mg film-coated tablets.
• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Undesirable Side Effects Of Hyzaar Tablets

• Cough, upper airway infection, congestion in the nose, sinusitis, sinus disorder
• Diarrhea, abdominal pain, nausea, indigestion
• Muscle pain or cramps, leg pain, back pain
• Insomnia, headache, dizziness
• Weakness, tiredness, chest pain
• Increased potassium levels (which can cause an abnormal heart rhythm), decreased
• Hemoglobin levels
• Changes in kidney function including kidney failure
• Too low sugar in the blood (hypoglycemia).

Pregnancy & Breastfeeding Precautions While Taking Hyzaar Tablets

• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.

Warnings & Special Precautions while Taking Hyzaar Tablets

• Talk to your doctor or pharmacist before taking this combination:

1. if you have previously suffered from swelling of the face, lips, throat, or tongue
2. if you take diuretics
3. if you are on a salt-restricted diet
4. if you have or have had severe vomiting and/or diarrhea
5. if you have heart failure
6. if your liver function is impaired
7. if you have narrow arteries to your kidneys (renal artery stenosis) or only have one functioning kidney, or you have recently had a kidney transplant
8. if you have narrowing of the arteries (atherosclerosis), angina pectoris (chest pain due to poor heart function)
9. if you have ‘aortic or mitral valve stenosis (narrowing of the valves of the heart) or ‘hypertrophic cardiomyopathy (a disease-causing thickening of heart muscle)
10. if you are diabetic
11. if you have had gout
12. if you have or have had an allergic condition, asthma, or a condition that causes joint pain, skin rashes, and fever (systemic lupus erythematosus)
13. if you have high calcium or low potassium levels or you are on a low potassium diet
14. if you need to have an anesthetic (even at the dentist) or before surgery, or if you are going to have tests to check your parathyroid function, you must tell the doctor or medical staff that you are taking losartan potassium and hydrochlorothiazide tablets
15. if you suffer from primary hyperaldosteronism (a syndrome associated with increased secretion of the hormone aldosterone by the adrenal gland, caused by an abnormality within the gland)
16. if you are taking any of the following medicines used to treat high blood pressure: an ACEinhibitor, aliskiren.

• Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including medicines obtained without a prescription.

Storage Conditions Of Hyzaar Tablets

• Store below 25°c
• Don’t refrigerate
• Keep this medicine out of the sight and reach of children.
• Store in the original package to protect from moisture.
• Do not use this medicine after the expiry date which is stated on the box/blisters/label. The expiry date refers to the last day of the month.