Actosmet 15 850Mg | 56Tab

• Actosmet 15/850,  56 Tablets

Scientific Name

• Pioglitazone 15 Mg + Metformin 850 Mg Tablets

Category Of Actosmet 15/850 Tablets

• Oral Anti-Diabetic Drugs

Mechanism Of Action Of Pioglitazone & Metformin

• Pioglitazone is a selective agonist at peroxisome proliferator-activated receptor-gamma (PPARγ) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver.4,2 Activation of PPARγ increases the transcription of insulin-responsive genes involved in the control of glucose and lipid production, transport, and utilization.
• Through this mechanism, pioglitazone both enhances tissue sensitivity to insulin and reduces the hepatic production of glucose
• Metformin decreases blood glucose levels by decreasing hepatic glucose production (also called gluconeogenesis)
• Metformin decreases the intestinal absorption of glucose
• Metformin increases insulin sensitivity by increasing peripheral glucose uptake and utilization

Therapeutic Indications Of Actosmet 15/850 Tablets

• It is used to lower blood sugar levels in patients with diabetes mellitus type 2 (non-insulin-dependent). It is used when diet and exercising have failed to control your diabetes
• Method Of Administration Of Actosmet 15/850 Tablets
• Individualize the starting dose based on the patient’s current regimen and adjust the dosing based on effectiveness and tolerability while not exceeding the maximum recommended daily dose of pioglitazone 45 mg and metformin 2550 mg
• Give in divided daily doses with meals to reduce the gastrointestinal effects due to metformin
• Monitor patients for adverse events related to fluid retention after initiation and dose increases
• Doses may be changed in special conditions so always follow your doctor's or pharmacist's instructions.
• If you take more than you should, talk to a doctor or go to the hospital straight away.
• If you forget to take a dose, take it as soon as you remember it unless it is nearly time for your next dose.
• Do not take a double dose (two doses at the same time) to make up for the forgotten dose.

Undesirable Side Effects Of Actosmet 15/850 Tablets

• Although the following side effects are not common in everyone, some patients may complain from:

1. upper respiratory tract infection
2. edema
3. diarrhea
4. headache
5. weight gain.

Pregnancy & Breastfeeding Precautions While Taking Actosmet 15/850 Tablets

• If you are pregnant or breastfeeding, think you may be pregnant or are planning to have a baby, ask your doctor or pharmacist for advice before taking this medicine.
• Your doctor will discuss the possible risks and benefits of using this medicine during pregnancy and breast-feeding